Onfi Dosage

Generic name: clobazam
Drug class: Benzodiazepine anticonvulsants

Recommended Adult Dosing

Dosage forms:  TAB: 10 mg, 20 mg; SUSP: 2.5 mg per mL

Seizures, Lennox-Gastaut syndrome

[adjunct tx, <30 kg]

Dose: 10 mg PO bid; Start: 5 mg PO qd x1wk, then 5 mg PO bid x1wk; Max: 20 mg/day; Info: taper dose by 5-10 mg/day qwk to D/C

[adjunct tx, >30 kg]

Dose: 20 mg PO bid; Start: 5 mg PO bid x1wk, then 10 mg PO bid x1wk; Max: 40 mg/day; Info: in elderly pts or CYP2C19 poor metabolizers, start 5 mg PO qd x1wk, then 5 mg PO bid x1wk, then 10 mg PO bid; taper dose by 5-10 mg/day qwk to D/C

Renal dosing

CrCl >30: no adjustment; CrCl <30 or ESRD: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: start 5 mg PO qd x1wk, then 5 mg PO bid x1wk, then 10 mg PO bid; Child-Pugh Class C: not defined

SRC: NLM .