Osimertinib Dosage

Generic name: osimertinib
Brand name: Tagrisso
Drug class: EGFR inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 40 mg, 80 mg

Non-small cell lung CA

[adjuvant tx]

Dose: 80 mg PO qd for up to 3y; Start: after tumor resection; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations

[metastatic dz, first-line tx]

Dose: 80 mg PO qd; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations

[metastatic dz, previously treated pts]

Dose: 80 mg PO qd; Info: for pts w/ EGFR T790M mutations

Renal dosing

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A and B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .