Osmolex ER Dosage

Generic name: amantadine
Brand names: Gocovri, Osmolex ER
Drug class: Dopaminergic antiparkinsonism agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  ER TAB: 129 mg, 193 mg, 258 mg

Parkinson dz

[129-322 mg PO qam]

Start: 129 mg PO qam, may incr. dose qwk; Max: 322 mg/day; Info: do not cut/crush/chew tab; taper dose gradually to 129 mg/day x1-2wk to D/C

Extrapyramidal sx

[129-322 mg PO qam]

Start: 129 mg PO qam, may incr. dose qwk; Max: 322 mg/day; Info: do not cut/crush/chew tab; taper dose gradually to 129 mg/day x1-2wk to D/C

Renal dosing

CrCl 60-90: give usual dose q24h, may incr. dose >qwk; CrCl 30-59: give usual dose q48h, may incr. dose >q3wk; CrCl 15-29: give usual dose q96h, may incr. dose >q4wk; CrCl <15: contraindicated

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .