Oxtellar XR Dosage

Generic name: oxcarbazepine
Drug class: Dibenzazepine anticonvulsants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  ER TAB: 150 mg, 300 mg, 600 mg

Partial seizures

[1200-2400 mg PO qd]

Start: 600 mg PO qd x1wk, incr. by 600 mg/day qwk; Info: consider screening pts of genetically at-risk ancestry (see pkg insert) for HLA-B*1502 allele before initiating tx; in elderly pts consider start 300-450 mg PO qd x1wk, incr. by 300-450 mg/day qwk; dose adjustment may be needed during pregnancy and/or postpartum; may need higher ER dose when converting from IR form; give on empty stomach 1h before or 2h after food; do not cut/crush/chew tab; taper dose gradually to D/C

Renal dosing

[adjust dose amount]

CrCl <30: start 300 mg qd x1wk, incr. by 300-450 mg/day qwk

HD/PD: avoid use; Info: use IR form

Hepatic dosing

[see below]

mild-mod impairment: no adjustment; severe impairment: not defined

Recommended Peds Dosing

Dosage forms:  ER TAB: 150 mg, 300 mg, 600 mg

Partial seizures

[6 yo and older, 20-29 kg]

Dose: 900 mg PO qd; Start: 8-10 mg/kg/dose PO qd x1wk, incr. by 8-10 mg/kg/day qwk; Info: consider screening pts of genetically at-risk ancestry (see pkg insert) for HLA-B*1502 allele before initiating tx; may need higher ER dose when converting from IR form; give on empty stomach 1h before or 2h after food; do not cut/crush/chew tab; taper dose gradually to D/C

[6 yo and older, 29.1-39 kg]

Dose: 1200 mg PO qd; Start: 8-10 mg/kg/dose PO qd x1wk, incr. by 8-10 mg/kg/day qwk; Info: consider screening pts of genetically at-risk ancestry (see pkg insert) for HLA-B*1502 allele before initiating tx; may need higher ER dose when converting from IR form; give on empty stomach 1h before or 2h after food; do not cut/crush/chew tab; taper dose gradually to D/C

[6 yo and older, >39 kg]

Dose: 1800 mg PO qd; Start: 8-10 mg/kg up to 600 mg PO qd x1wk, incr. by 8-10 mg/kg/day up to 600 mg/day qwk; Info: consider screening pts of genetically at-risk ancestry (see pkg insert) for HLA-B*1502 allele before initiating tx; may need higher ER dose when converting from IR form; give on empty stomach 1h before or 2h after food; do not cut/crush/chew tab; taper dose gradually to D/C

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[see below]

mild-mod impairment: no adjustment; severe impairment: not defined

SRC: NLM .