Pemazyre Dosage

Recommended Adult Dosing

Dosage forms:  TAB: 4.5 mg, 9 mg, 13.5 mg

Restricted Distribution in US

[1-855-452-5234 or www.pemazyre.com for more info]

Cholangiocarcinoma, unresectable locally advanced or metastatic

[13.5 mg PO qd on days 1-14 of 21-day cycle]

Info: for pts w/ previously treated dz w/ fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement; do not cut/crush/chew tab

Myeloid/lymphoid neoplasm, relapsed or refractory

[13.5 mg PO qd]

Info: for pts w/ fibroblast growth factor receptor 1 (FGFR1) rearrangement; do not cut/crush/chew tab

Renal dosing

[cholangiocarcinoma, unresectable locally advanced or metastatic]

eGFR 15-29: 9 mg qd on days 1-14 of 21-day cycle; eGFR <15: not defined

HD: no adjustment; no supplement; PD: not defined

[myeloid/lymphoid neoplasm, relapsed or refractory]

eGFR 15-29: 9 mg qd; eGFR <15: not defined

HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

[cholangiocarcinoma, unresectable locally advanced or metastatic]

bilirubin 1.1-3x ULN and any AST: no adjustment; bilirubin >3x ULN and any AST: 9 mg qd on days 1-14 of 21-day cycle

[myeloid/lymphoid neoplasm, relapsed or refractory]

bilirubin 1.1-3x ULN and any AST: no adjustment; bilirubin >3x ULN and any AST: 9 mg qd