Pentamidine (Systemic) Dosage

Recommended Adult Dosing

Dosage forms:  INJ

PCP tx, mod-severe

[4 mg/kg/dose IV/IM q24h x21 days]

Info: not 1st-line agent; IV preferred to IM; may consider decr. dose to 3 mg/kg/dose IV/IM q24h if toxicities occur

PCP prophylaxis

[300 mg NEB q4wk]

Info: not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial w/ 6 mL sterile water; do not mix w/ other nebulized meds

Human African trypanosomiasis

[4 mg/kg/dose IM/IV q24h x7 days]

Info: for 1st stage dz caused by Trypanosoma brucei gambiense

Renal dosing

[IV/IM route]

CrCl 10-50: 3 mg/kg/dose IV/IM q24h; CrCl <10: 4 mg/kg/dose IV/IM q48h

HD: 4 mg/kg/dose IV/IM q48h; no supplement after dialysis; PD: 4 mg/kg/dose IV/IM q48h; no supplement

[NEB route]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised if IV/IM route

Recommended Peds Dosing

Dosage forms:  INJ

PCP tx

[>4 mo]

Dose: 4 mg/kg/dose IV/IM q24h x21 days; Info: not 1st-line agent; IV preferred to IM; may consider decr. dose to 3 mg/kg/dose IV/IM q24h if toxicities occur; may switch to PO regimen to complete course if improvement after 7-10 days

PCP prophylaxis

[5 yo and older]

Dose: 300 mg NEB q4wk; Info: not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial w/ 6 mL sterile water; do not mix w/ other nebulized meds

Human African trypanosomiasis

[>4 mo]

Dose: 4 mg/kg/dose IM/IV q24h x7 days; Info: for 1st stage dz caused by Trypanosoma brucei gambiense

Renal dosing

[IV/IM route]

CrCl 10-29: give usual dose IV/IM q36h; CrCl <10: give usual dose IV/IM q48h

HD: give usual dose IV/IM q48h; no supplement after dialysis; PD: give usual dose IV/IM q48h; no supplement

[NEB route]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised if IV/IM route