Prograf Dosage

Generic name: tacrolimus (oral/injection)
Drug class: Calcineurin inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  CAP: 0.5 mg, 1 mg, 5 mg; GRANULE: 0.2 mg per pkt, 1 mg per pkt; INJ: various

Heart transplant rejection prophylaxis

[0.075 mg/kg/day PO divided q12h]

Start: >6h post-transplant; Alt: 0.01 mg/kg/day IV infusion; Info: adjust dose based on serum levels

Liver transplant rejection prophylaxis

[0.1-0.15 mg/kg/day PO divided q12h]

Start: >6h post-transplant; Alt: 0.03-0.05 mg/kg/day IV infusion; Info: adjust dose based on serum levels

Kidney transplant rejection prophylaxis

[0.1-0.2 mg/kg/day PO divided q12h]

Start: w/in 24h post-transplant; delay if renal fxn not adequate; Alt: 0.03-0.05 mg/kg/day IV infusion; Info: adjust dose based on serum levels

Lung transplant rejection prophylaxis

[0.075 mg/kg/day PO divided q12h]

Start: >6h post-transplant; Alt: 0.01-0.03 mg/kg/day IV infusion; Info: adjust dose based on serum levels; pts w/ cystic fibrosis may require higher doses

Renal dosing

[kidney transplant]

renal impairment: give lowest recommended dose, may consider further dose decr.; postop oliguria: start 6-24h post-transplant; may delay until renal fxn adequate

HD/PD: not defined

[all other transplants]

renal impairment: give lowest recommended dose, may consider further dose decr.

HD/PD: not defined

Hepatic dosing

hepatic impairment: give lowest recommended dose, may consider further dose decr.; Child-Pugh Score >10: decr. dose, amount not defined

SRC: NLM .