Pyrimethamine Dosage

Generic name: pyrimethamine
Brand name: Daraprim
Dosage form: oral tablet (25 mg)
Drug class: Miscellaneous antimalarials

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg

Toxoplasmosis

[*prophylaxis, primary]

Dose: 50-75 mg PO qwk; Info: not 1st-line agent; give w/ dapsone, leucovorin

[treatment, <60 kg]

Dose: 200 mg PO x1, then 50 mg PO qd for at least 6wk; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[treatment, >60 kg]

Dose: 200 mg PO x1, then 75 mg PO qd for at least 6wk; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[*maintenance tx, <60 kg]

Dose: 25 mg PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

[*maintenance tx, >60 kg]

Dose: 50 mg PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

PCP prophylaxis

[50-75 mg PO qwk]

Info: not 1st-line agent; give w/ dapsone, leucovorin

Cystoisosporiasis

[acute infection treatment]

Dose: 50-75 mg PO qd; Info: not 1st-line agent; give w/ leucovorin

[chronic maintenance therapy]

Dose: 25 mg PO qd; Info: not 1st-line agent; give w/ leucovorin

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .