Repatha Dosage

Recommended Adult Dosing

Dosage forms:  INJ (SureClick auto-injector): 140 mg; INJ (pre-filled syringe): 140 mg per mL; INJ (Pushtronex on-body injector): 420 mg

Cardiovascular event risk reduction

[140 mg SC q2wk]

Alt: 420 mg SC qmo; Info: for pts w/ established CVD

Primary hyperlipidemia, adjunct tx

[140 mg SC q2wk]

Alt: 420 mg SC qmo

Heterozygous familial hypercholesterolemia, adjunct tx

[140 mg SC q2wk]

Alt: 420 mg SC qmo

Homozygous familial hypercholesterolemia, adjunct tx

[420 mg SC qmo or 420 mg SC q2wk]

Start: 420 mg SC qmo, may incr. to 420 mg SC q2wk after 12wk if inadequate response; Info: may start 420 mg SC q2wk if pt on lipid apheresis

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined