Rifabutin Dosage

Generic name: rifabutin
Brand name: Mycobutin
Drug class: Rifamycin derivatives

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 150 mg

MAC prophylaxis, primary

[300 mg PO qd]

Alt: 150 mg PO bid; Info: not 1st-line agent; give w/ food

MAC prophylaxis, secondary

[300 mg PO qd]

Alt: 150 mg PO bid; Info: part of multi-drug regimen; give w/ food

MAC tx, disseminated

[300 mg PO qd]

Alt: 150 mg PO bid; Info: part of multi-drug regimen; give w/ food

Tuberculosis, active

[5 mg/kg/dose PO qd for at least 6mo]

Max: 300 mg/dose; Alt: 5 mg/kg/dose PO 5x/wk for at least 6mo if directly observed tx; Info: part of multi-drug regimen; give w/ food; duration varies by infection site/severity

Tuberculosis, latent

[individualize dose x4mo]

Info: not 1st-line agent; recommendations may vary based on concomitant antiretrovirals if HIV-positive, see drug interactions

H. pylori infection

[300 mg PO qd x10 days]

Info: part of multi-drug regimen; search H. pylori Tx Regimens for guidelines; give w/ food

Renal dosing

[adjust dose amount]

CrCl <30: decr. usual dose by 50%

HD/PD: not defined

Hepatic dosing

mild impairment: no adjustment; mod-severe impairment: not defined

SRC: NLM .