Rybrevant Dosage

Generic name: amivantamab-vmjw
Drug class: Miscellaneous antineoplastics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Adult Dosing

Dosage forms:  INJ

Non-small cell lung CA, locally advanced or metastatic

[<80 kg]

Dose: 350 mg IV x1 on day 1 at wk 1, then 700 mg IV x1 on day 2 at wk 1, then 1050 mg IV qwk x3wk, then 1050 mg IV q2wk; Info: for pts w/ EGFR exon 20 insertion mutations w/ progressive dz on or after platinum-based chemo

[>80 kg]

Dose: 350 mg IV x1 on day 1 at wk 1, then 1050 mg IV x1 on day 2 at wk 1, then 1400 mg IV qwk x3wk, then 1400 mg IV q2wk; Info: for pts w/ EGFR exon 20 insertion mutations w/ progressive dz on or after platinum-based chemo

Renal dosing

CrCl >29: no adjustment; CrCl <29: not defined

HD/PD: not defined

Hepatic dosing

bilirubin <1.5x ULN and any AST: no adjustment; bilirubin >1.5x ULN: not defined

SRC: NLM .