Selzentry Dosage

Generic name: maraviroc
Drug class: Chemokine receptor antagonist

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 75 mg, 150 mg, 300 mg; SOL: 20 mg per mL

HIV infection, CCR5-tropic

[combo w/ no CYP3A strong inhibitors or CYP3A strong inducers]

Dose: 300 mg PO bid; Info: for tx-experienced pts; see Drug Interactions for specific drugs; tropism testing required before tx

[combo w/ CYP3A strong inhibitor with or w/o CYP3A strong inducer]

Dose: 150 mg PO bid; Info: for tx-experienced pts; see Drug Interactions for specific drugs; tropism testing required before tx

[combo w/ CYP3A strong inducer]

Dose: 600 mg PO bid; Info: for tx-experienced pts; see Drug Interactions for specific drugs; tropism testing required before tx

Renal dosing

[combo w/ no CYP3A strong inhibitors or CYP3A strong inducers]

CrCl <30 and postural hypotension sx: 150 mg bid; Info: see Drug Interactions for specific drugs

HD: 150 mg bid if postural hypotension; no supplement after dialysis; PD: not defined; Info: see Drug Interactions for specific drugs

[combo w/ CYP3A strong inhibitor and/or CYP3A strong inducer]

CrCl <30: contraindicated; Info: see Drug Interactions for specific drugs

HD: contraindicated; PD: not defined; Info: see Drug Interactions for specific drugs

Hepatic dosing

[combo w/ no CYP3A strong inhibitors]

hepatic impairment: caution advised

[combo w/ CYP3A strong inhibitor]

moderate impairment: no adjustment, monitor for toxicity; severe impairment: not defined

SRC: NLM .