Seroquel Dosage

Generic name: quetiapine
Brand names: SEROquel, SEROquel XR
Drug class: Atypical antipsychotics

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg

Schizophrenia

[150-750 mg/day PO divided bid-tid]

Start: 25 mg PO bid, then incr. by 50-150 mg/day up to 300-400 mg/day PO divided bid-tid by day 4, then may adjust dose by 50-100 mg/day no more frequently than q2 days prn; Max: 800 mg/day; Info: start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. WBC

Bipolar I disorder, manic

[200-400 mg PO bid]

Start: 50 mg PO bid, then incr. by 100 mg/day up to 200 mg PO bid by day 4, then may incr. by 200 mg/day prn; Max: 800 mg/day; Info: for acute monotherapy or acute or maint. lithium or valproate adjunct; start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. WBC

Bipolar disorder, acute depressive

[300 mg PO qhs]

Start: 50 mg PO qhs x1, then 100 mg PO qhs x1, then 200 mg PO qhs x1, then 300 mg PO qhs; Max: 300 mg/day; Info: start 50 mg PO qhs in elderly or debilitated pts, then incr. by 50 mg/day; D/C if ANC <1000; consider D/C if unexplained decr. WBC

Generalized anxiety disorder, tx-resistant

[50-150 mg PO qd]

Start: 25 mg PO qd, then incr. by 25-50 mg/day; Max: 300 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. WBC

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

hepatic impairment: start 25 mg qd, incr. 25-50 mg/day

SRC: NLM .