Siklos Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 100 mg, 1000 mg
Sickle cell dz
- [15-35 mg/kg/dose PO qd]
- Start: 15 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: titrate by 5 mg/kg/day q8wk; may split tab; round dose to nearest 50 mg or 100 mg
Renal dosing
- [adjust dose amount]
- CrCl <60: decr. usual dose by 50%
- HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement
Hepatic dosing
- [not defined]
SRC: NLM .